Biotransformation of 4-methylcoumarins by cambial meristematic cells of Camptotheca acuminata.

ABSTRACT: Cambial meristematic cell (CMC) suspension cultures were investigated as a new biotransformation system for the first time. Four 4-methylcoumarins substrates were transformed by CMCs of Camptotheca acuminata into four corresponding products, including 4,8-dimethylcoumarin-7-O-β-d-glucopyranoside (I-1), 4,7-dimethylcoumarin-6-O-β-d-glucopyranoside (II-1), 6-hydroxy-7-methoxyl-4- methylcoumarin (III-1), and 4,7-dimethylcoumarin-5-O-β-d-glucopyranoside (IV-1), of which I-1, II-1, and IV-1 were new compounds. In addition, the biotransformation time and the amount of substrate were investigated to compare the biotransformation rate and optimize the biotransformation conditions of the four substrates in C. acuminata CMCs suspension cultures. The results suggest

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9062171 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature