Non-destructive mechanical assessment for optimization of 3D bioprinted soft tissue scaffolds.

ABSTRACT: Characterizing the mechanical properties of engineered tissue constructs provides powerful insight into the function of engineered tissues for their desired application. Current methods of mechanical characterization of soft hydrogels used in tissue engineering are often destructive and ignore the effect of 3D bioprinting on the overall mechanical properties of a whole tissue construct. This work reports on using a non-destructive method of viscoelastic analysis to demonstrate the influence of bioprinting strategy on mechanical properties of hydrogel tissue scaffolds. Structure-function relationships are developed for common 3D bioprinting parameters such as printed fiber size, printed scaffold pattern, and bioink formulation. Further studies include mechanical properties analysis during d

SUBMITTER: Godau B 

PROVIDER: S-EPMC9062268 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature