Enhancing the antitumor activity of tea polyphenols encapsulated in biodegradable nanogels by macromolecular self-assembly.

ABSTRACT: Nanogels (NGs) with desirable stability have emerged as a promising platform for biomedical applications. Herein, a convenient approach was developed to encapsulate and protect tea polyphenols (TPs) by macromolecular self-assembly of lysozyme (Ly) and carboxymethyl cellulose (CMC) through a heating treatment. Biodegradable Ly-CMC NGs were formed on the basis of molecules driven by electrostatic interaction and hydrophobic forces. The particle size and morphology of the Ly-CMC NGs were analyzed using a Malvern particle size analyzer, fluorescence spectrophotometer, and scanning electron microscope. The results showed that the heated NGs were spherical with better stability and smaller particle size. The encapsulation efficiency of TP-loaded NGs was 89.05 ± 3.14%, and it indicated that the L

SUBMITTER: Liu C 

PROVIDER: S-EPMC9062372 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature