Synthesis and biological activities of petrosiols B and D.

ABSTRACT: A divergent total synthesis of natural diacetylenic tetraols, petrosiol B and petrosiol D, was accomplished by taking advantage of a carbohydrate chiral template. In particular, petrosiol B, which is the first total synthesis so far, was achieved in 13 linear steps with a 10% overall yield applying Ohira-Bestmann homologation, NaH-mediated dehydrobromination, and Cu(i)-catalyzed Cadiot-Chodkiewicz coupling as the key reaction steps. The synthetic petrosiols B and D were subjected to the study on differentiation activities toward neuronal progenitor PC12 cells. Our results suggested that both petrosiol B and petrosiol D could induce the differentiation of neuronal progenitor PC12 cells via the enhancement of Nrf2 activity. By comparing petrosiols B, D and their natural homologue E, p

SUBMITTER: Geng J 

PROVIDER: S-EPMC9062523 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature