Role of hydrogen sulfide in subarachnoid hemorrhage.

ABSTRACT: Subarachnoid hemorrhage (SAH) is a common acute and severe disease worldwide, which imposes a heavy burden on families and society. However, the current therapeutic strategies for SAH are unsatisfactory. Hydrogen sulfide (H₂ S), as the third gas signaling molecule after carbon monoxide and nitric oxide, has been widely studied recently. There is growing evidence that H₂ S has a promising future in the treatment of central nervous system diseases. In this review, we focus on the effects of H₂ S in experimental SAH and elucidate the underlying mechanisms. We demonstrate that H₂ S has neuroprotective effects and significantly reduces secondary damage caused by SAH via antioxidant, antiinflammatory, and antiapoptosis mechanisms, and by alleviating ce

SUBMITTER: Lu D 

PROVIDER: S-EPMC9062544 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature