Trans-anethole Ameliorates Intestinal Injury Through Activation of Nrf2 Signaling Pathway in Subclinical Necrotic Enteritis-Induced Broilers.

ABSTRACT: This study was conducted to investigate the alleviative effects of trans-anethole (TA) on intestinal oxidative stress by enhancing the activities of intestinal antioxidant enzymes and activating the Nrf2 signaling pathway in subclinical necrotic enteritis (NE) infected broilers. A total of 192 1-day-old male Arbor Acres broilers were randomly allocated into three treatment groups: (1) control (CON); (2) subclinical NE challenge (NE); (3) NE challenge + 600 mg/kg TA (NE+TA600). Subclinical NE was induced by oral administration of live coccidiosis vaccine containing 2 × 10⁴ oocysts at 10 days of age and 2 ml of Clostridium perfringens type A solution (3 × 10⁸ CFU/ml) daily from days 14 to 19. The results showed that NE infection led to a severe decline (

SUBMITTER: Yu C 

PROVIDER: S-EPMC9062583 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature