Evidence of immunometabolic dysregulation and airway dysbiosis in athletes susceptible to respiratory illness.

ABSTRACT:

Background

Respiratory tract infection (RTI) is a leading cause of training and in-competition time-loss in athlete health. The immune factors associated with RTI susceptibility remain unclear. In this study, we prospectively characterise host immune factors in elite athletes exhibiting RTI susceptibility.

Methods

Peripheral blood lymphocyte flow cytometry phenotyping and 16S rRNA microbial sequencing of oropharyngeal swabs was performed in a prospective elite athlete cohort study (n = 121). Mass cytometry, peripheral blood mononuclear cell (PBMC) stimulation and plasma metabolic profiling was performed in age-matched highly-susceptible (HS) athletes (≥4RTI in last 18 months) (n = 22) compared to non-susceptible (NS) (≤1RTI in last 18 months) (n = 23) athletes. Findings were

SUBMITTER: Cuthbertson L 

PROVIDER: S-EPMC9062742 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature