Open-porous magnesium-based scaffolds withstand in vitro corrosion under cyclic loading: A mechanistic study.

ABSTRACT: The successful application of magnesium (Mg) alloys as biodegradable bone substitutes for critical-sized defects may be comprised by their high degradation rate resulting in a loss of mechanical integrity. This study investigates the degradation pattern of an open-porous fluoride-coated Mg-based scaffold immersed in circulating Hanks' Balanced Salt Solution (HBSS) with and without in situ cyclic compression (30 N/1 Hz). The changes in morphological and mechanical properties have been studied by combining in situ high-resolution X-ray computed tomography mechanics and digital volume correlation. Although in situ cyclic compression induced acceleration of the corrosion rate, probably due to local disruption of the coating layer where fatigue microcracks were formed, no c

SUBMITTER: Bonithon R 

PROVIDER: S-EPMC9062748 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature