Complex trait methylation scores in the prediction of major depressive disorder.

ABSTRACT:

Background

DNA methylation (DNAm) is associated with time-varying environmental factors that contribute to major depressive disorder (MDD) risk. We sought to test whether DNAm signatures of lifestyle and biochemical factors were associated with MDD to reveal dynamic biomarkers of MDD risk that may be amenable to lifestyle interventions.

Methods

Here, we calculated methylation scores (MS) at multiple p-value thresholds for lifestyle (BMI, smoking, alcohol consumption, and educational attainment) and biochemical (high-density lipoprotein (HDL) and total cholesterol) factors in Generation Scotland (GS) (N=9,502) and in a replication cohort (ALSPAC_adults, N=565), using CpG sites reported in previous well-powered methylome-wide association studies. We also compared the

SUBMITTER: Barbu MC 

PROVIDER: S-EPMC9062752 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature