Optimising the treatment for uncomplicated acute appendicitis (OPTIMA trial): a protocol for a multicentre, randomised, double-blinded placebo-controlled study.

ABSTRACT:

Introduction

Emerging evidence has shown that an antibiotic first strategy is a viable treatment option for uncomplicated acute appendicitis (AA). Although there has recently been an interest and increase in the use of antibiotics as the primary strategy for treating uncomplicated AA, there is no consensus regarding the optimum antibiotic regimen. In particular, the long-term outcomes of different antibiotic regimens, such as the recurrence rate, still lack evidence. Given that the flora of the appendix is mainly anaerobic bacteria, we hypothesised that antianaerobe regimens could decrease the recurrence rate compared with those that did not include antianaerobic antibiotics.

Methods and analysis

The OPTIMA(Optimising the treatment for uncomplicated acute appendicitis) trial

SUBMITTER: Wu J 

PROVIDER: S-EPMC9062814 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature