Properties of immature and mature dendritic cells: phenotype, morphology, phagocytosis, and migration.

ABSTRACT: Dendritic cells (DCs) are antigen-presenting cells that play an important role in connecting the innate and adaptive immunity of the immune system. To mediate innate and adaptive immunity, DCs pass through two stages: immature and mature. The change of phenotype is closely associated with the morphological and functional characteristics of DCs. Understanding these properties of DCs is important in the context of recent efforts on the developments of biomaterials-based cancer vaccine. In this paper, the morphological and phenotypical status of DCs in both stages were compared, and their relationship to the phagocytic and migratory ability of the cells was studied using bone-marrow derived dendritic cells (BMDCs). Immature DCs were of a circular shape and expressed low levels of costimulator

SUBMITTER: Kim MK 

PROVIDER: S-EPMC9063012 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature