Systematic analysis of prognostic significance, functional enrichment and immune implication of STK10 in acute myeloid leukemia.

ABSTRACT:

Background

Despite deeper understanding of the genetic landscape of acute myeloid leukemia (AML), the improvement of survival is still a great challenge. STK10 is overexpressed in several cancers with functions varying according to cancer types. But the functions of STK10 in AML has never been reported.

Methods

We analyzed the expression, prognosis and potential functions of STK10 utilizing public web servers. Metascape and the String database were used for functional and protein-protein interaction analyses.

Results

We found STK10 was enriched in blood & immune cells and overexpressed in AML. High STK10 expression was associated with poor overall survival, which was also identified in the subgroups of patients ≤ 60 years old and patients with non-high-risk cytogeneti

SUBMITTER: Bi L 

PROVIDER: S-EPMC9063138 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature