Irisin mediates beiging of adipose-derived mesenchymal stem cells through binding to TRPC3.

ABSTRACT:

Background

Beiging of white fat plays an important role in energy metabolism. Beige adipocytes contribute to the regulation of body weight and body temperature through expenditure of chemical energy to produce heat, and they have therefore recently attracted considerable attention as potential targets for therapeutic approaches in metabolic disorders, including obesity. All adipocytes, including beige adipocytes, differentiate from mesenchymal stem cells (MSCs), which may provide an important path for clinical intervention; however, the mechanism of beiging of human adipose cell-derived MSCs is not fully understood. Here, we provide insights on the role of IRISIN, which is known to be secreted by skeletal muscle and promote beiging of white fat.

Results

We established an IRI

SUBMITTER: Xue C 

PROVIDER: S-EPMC9063202 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature