NcRNAs-mediated high expression of TIMM8A correlates with poor prognosis and act as an oncogene in breast cancer.

ABSTRACT:

Background

Breast cancer is notorious for its increasing incidence for decades. Ascending evidence has demonstrated that translocase of inner mitochondrial membrane (TIMM) proteins play vital roles in progression of several types of human cancer. However, the biological behaviors and molecular mechanisms of TIMM8A in breast cancer remain not fully illustrated.

Methods

Pan-cancer analysis was firstly performed for TIMM8A's expression and prognosis by Oncomine database. Subsequently, TIMM8A-related noncoding RNAs (ncRNAs) were identified by a series of bioinformatics analyses and dual-luciferase reporter assay, including expression analysis, correlation analysis, and survival analysis. Moreover, the effect of TIMM8A on breast cancer proliferation and apoptosis was evaluated in

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9063222 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature