TReasure: R-based GUI package analyzing tRNA expression profiles from small RNA sequencing data.

ABSTRACT:

Background

Recent deep sequencing technologies have proven to be valuable resources to gain insights into the expression profiles of diverse tRNAs. However, despite these technologies, the association of tRNAs with diverse diseases has not been explored in depth because analytical tools are lacking.

Results

We developed a user-friendly tool, tRNA Expression Analysis Software Utilizing R for Easy use (tReasure), to analyze differentially expressed tRNAs (DEtRNAs) from deep sequencing data of small RNAs using R packages. tReasure can quantify individual mature tRNAs, isodecoders, and isoacceptors. By adopting stringent mapping strategies, tReasure supports the precise measurement of mature tRNA read counts. The whole analysis workflow for determining DEtRNAs (uploading FASTQ f

SUBMITTER: Lee JO 

PROVIDER: S-EPMC9063265 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature