Follicle stimulating hormone promotes production of renin through its receptor in juxtaglomerular cells of kidney.

ABSTRACT:

Background

Post-menopausal hypertension has been attributed solely to declining estrogen levels. The purpose of the research is to elucidate the mechanism by which follicle stimulating hormone(FSH) increases renin production involved in the regulation of blood pressure.

Methods

The expression of follicle stimulating hormone receptors (FSHRs) in renal juxtaglomerular cells and a As4.1 juxtaglomerular mouse cell line was evaluated. We established a mouse model by ovariectomy (OVX). Ovariectomized mice were treated with gonadotropin-releasing hormone agonist (GnRHa) (OVX + GnRHa). Ovariectomized mice initially received physiological doses of estrogen and were then injected with recombinant FSH (OVX + E + FSH).

Results

We found that FSHR was expressed in mouse renal juxta

SUBMITTER: Yu Z 

PROVIDER: S-EPMC9063271 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature