New neurons in old brains: implications of age in the analysis of neurogenesis in post-mortem tissue.

ABSTRACT: Adult neurogenesis, the proliferation and integration of newly generated neurons, has been observed in the adult mammalian hippocampus of many species. Numerous studies have also found adult neurogenesis in the human hippocampus, but several recent high-profile studies have suggested that this process is considerably reduced in humans, occurring in children but not in adults. In comparison, rodent studies also show age-related decline but a greater degree of proliferation of new neurons in adult animals. These differences may represent biological species differences or could alternatively be explained by methodological differences in tissue handling and fixation. Here, we examine whether differences in the post-mortem interval between death and tissue fixation might impact subsequent detec

SUBMITTER: Terstege DJ 

PROVIDER: S-EPMC9063342 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature