CF₃: an overlooked chromophore in VCD spectra. A review of recent applications in structural determination.

ABSTRACT: The VCD spectra of several chiral compounds containing the CF₃ group are reviewed and analyzed. The list of compounds contains pharmaceutically relevant molecules as well as simple model molecules, having the value of case studies. In particular we point out the importance of the sign of the VCD band relative to some stretching normal mode of CF₃ in the region 1110-1150 cm^-1, as diagnostic of the configuration of stereogenic carbons C* to which the CF₃ group is bound: the correspondence (-) ↔ (R) and (+) ↔ (S) holds for 100% of 1-aryl-2,2,2-trifluoroethanols. DFT calculations confirm these conclusions, but for the rule established here they serve just as a check. This rule is tested on two new compounds, namely N-tert-butanes

SUBMITTER: Abbate S 

PROVIDER: S-EPMC9063343 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature