ITRAQ based proteomic analysis of PM_2.5 induced lung damage.

ABSTRACT: Haze pollution has become a global environmental problem, subsequently affecting air quality, climate, economy and human health. Notably, PM_2.5 (particulate matter with an aerodynamic diameter less than 2.5 micrometers) significantly accounts for a variety of adverse health effects, in particular pulmonary diseases such as asthma and lung cancer. Clinical diagnosis and medical treatment of the lung damage caused by PM_2.5 still remain significant challenges due to the lack of specific biomarkers and pathways. Here, we established a rat model of nonsurgical intratracheal instillation to investigate PM_2.5 exposure and employed iTRAQ based analytical technique and bioinformatics tools to identify putative biomarkers and pathways. We identified 163 differentiall

SUBMITTER: Xue Z 

PROVIDER: S-EPMC9063425 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature