Working with the natural complexity: Selection and characterization of black cohosh root extract for use in toxicology testing.

ABSTRACT: Black cohosh (Actaea racemosa L.) is a botanical supplement marketed to women of all ages. Due to paucity of data to assess the safe use, the National Toxicology Program (NTP) is evaluating the toxicity of black cohosh. The use of an authentic, quality material is imperative to generate robust data. Because botanical materials are complex mixtures with variable composition, the selection of a material is challenging. We describe selection and phytochemical characterization of an unformulated black cohosh root extract (i.e., an extract that serves as source material for a formulated product) to be used in the NTP assessments. A material was selected using a combination of non-targeted and targeted chemical analyses, including confirmation of authenticity, absence of contaminants and adulter

SUBMITTER: Waidyanatha S 

PROVIDER: S-EPMC9063431 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature