The dynamics of cell death patterns and regeneration during acute liver injury in mice.

ABSTRACT: Acute liver injury is a serious clinical syndrome with multiple causes and unclear pathological process. Here, CCl₄ - and D-galactosamine/lipopolysaccharide (D-gal/LPS)-induced acute liver injury was established to explore the cell death patterns and determine whether or not liver regeneration occurred. In CCl₄ -induced hepatic injury, three phases, including the early, progressive, and recovery phase, were considered based on alterations of serum transaminases and liver morphology. Moreover, in this model, cytokines exhibited double-peak fluctuations; apoptosis and pyroptosis persisted throughout all phases; autophagy occurred in the early and the progressive phases; and sufficient and timely hepatocyte regeneration was observed only during the recovery phase. All of

SUBMITTER: Shao S 

PROVIDER: S-EPMC9063440 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature