B Cell Characteristics at Baseline Predict Vaccination Response in RTX Treated Patients.

ABSTRACT:

Background

Vaccination is considered as most efficient strategy in controlling SARS-CoV-2 pandemic spread. Nevertheless, patients with autoimmune inflammatory rheumatic diseases receiving rituximab (RTX) are at increased risk to fail humoral and cellular responses upon vaccination. The ability to predict vaccination responses is essential to guide adequate safety and optimal protection in these patients.

Methods

B- and T- cell data before vaccination were evaluated for characteristics predicting vaccine responses in altogether 15 patients with autoimmune inflammatory rheumatic diseases receiving RTX. Eleven patients with rheumatoid arthritis (RA) on other therapies, 11 kidney transplant recipients (KTR) on regular immunosuppression and 15 healthy controls (HC) served as cont

SUBMITTER: Stefanski AL 

PROVIDER: S-EPMC9063458 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature