Angiotensin and Endothelin Receptor Structures With Implications for Signaling Regulation and Pharmacological Targeting.

ABSTRACT: In conjunction with the endothelin (ET) type A (ET_AR) and type B (ET_BR) receptors, angiotensin (AT) type 1 (AT₁R) and type 2 (AT₂R) receptors, are peptide-binding class A G-protein-coupled receptors (GPCRs) acting in a physiologically overlapping context. Angiotensin receptors (ATRs) are involved in regulating cell proliferation, as well as cardiovascular, renal, neurological, and endothelial functions. They are important therapeutic targets for several diseases or pathological conditions, such as hypertrophy, vascular inflammation, atherosclerosis, angiogenesis, and cancer. Endothelin receptors (ETRs) are expressed primarily in blood vessels, but also in the central nervous system or epithelial cells. They regulate blood pressure and cardiovascu

SUBMITTER: Speck D 

PROVIDER: S-EPMC9063481 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature