Single pulse heating of a nanoparticle array for biological applications.

ABSTRACT: With the ability to convert external excitation into heat, nanomaterials play an essential role in many biomedical applications. Two modes of nanoparticle (NP) array heating, nanoscale-confined heating (NCH) and macroscale-collective heating (MCH), have been found and extensively studied. Despite this, the resulting biological response at the protein level remains elusive. In this study, we developed a computational model to systematically investigate the single-pulsed heating of the NP array and corresponding protein denaturation/activation. We found that NCH may lead to targeted protein denaturation, however, nanoparticle heating does not lead to nanoscale selective TRPV1 channel activation. The excitation duration and NP concentration are primary factors that determine a window for targ

SUBMITTER: Xie C 

PROVIDER: S-EPMC9063739 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature