A facile method for fabricating a three-dimensional aligned fibrous scaffold for vascular application.

ABSTRACT: Vascular graft replacement remains the optimal treatment option for many vascular diseases despite advances in endovascular surgery. In this study, we proposed the use of surface topographical cues to align and maintain the phenotype of vascular smooth muscle cells (vSMCs) which were reported as one of the vital limitations for successful graft replacement. An auxiliary electrospinning setup has been developed to collect circumferentially aligned fibres on a 3D tubular format; this micro-architecture was found to be similar to the tunica media layer of blood vessels. The presence of aligned fibres served as a signaling modality to induce cell alignment and the maintenance of the contractile phenotype. vSMCs cultured on the 3D aligned fibrous substrate were found to exhibit better cell prol

SUBMITTER: Ng FL 

PROVIDER: S-EPMC9063778 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature