Ontology highlight
ABSTRACT:
SUBMITTER: Faulkner S
PROVIDER: S-EPMC9063854 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Faulkner Sarah S Maksimovic Igor I David Yael Y
Current opinion in chemical biology 20210620
Histone nonenzymatic covalent modifications (NECMs) have recently emerged as an understudied class of posttranslational modifications that regulate chromatin structure and function. These NECMs alter the surface topology of histone proteins, their interactions with DNA and chromatin regulators, as well as compete for modification sites with enzymatic posttranslational modifications. NECM formation depends on the chemical compatibility between a reactive molecule and its target site, in addition ...[more]