A circular RNA circ_0000115 in response to graphene oxide in nematodes.

ABSTRACT: Circular RNAs (circRNAs) play important roles in regulating various biological processes; however, their roles in regulating the toxicity of engineered nanomaterials (ENMs) are still unclear. Based on Illumina HiSeq2500 sequencing, we here identified 43 dysregulated circRNAs in graphene oxide (GO) (1 mg L^-1) exposed nematodes. Five of these candidate circRNAs could be further dysregulated by GO exposure in the range of μg L^-1. Using the RNA interference (RNAi) technique, we found that the alteration in expressions of circ_0000115, circ_0000247, and circ_0000665 mediated a protective response to GO exposure; however, the alteration in expressions of circ_0000201 and circ_0000308 mediated the toxicity induction of GO. In nematodes, the cir

SUBMITTER: Shi L 

PROVIDER: S-EPMC9063864 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature