Development of Azaindole-Based Frameworks as Potential Antiviral Agents and Their Future Perspectives.

ABSTRACT: The azaindole (AI) framework continues to play a significant role in the design of new antiviral agents. Modulating the position and isosteric replacement of the nitrogen atom of AI analogs notably influences the intrinsic physicochemical properties of lead compounds. The intra- and intermolecular interactions of AI derivatives with host receptors or viral proteins can also be fine tuned by carefully placing the nitrogen atom in the heterocyclic core. This wide-ranging perspective article focuses on AIs that have considerable utility in drug discovery programs against RNA viruses. The inhibition of influenza A, human immunodeficiency, respiratory syncytial, neurotropic alpha, dengue, ebola, and hepatitis C viruses by AI analogs is extensively reviewed to assess their plausible future poten

SUBMITTER: Urvashi 

PROVIDER: S-EPMC9063994 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature