Spectro-electrochemical assessments of DNA/BSA interactions, cytotoxicity, radical scavenging and pharmacological implications of biosensitive and biologically active morpholine-based metal(ii) complexes: a combined experimental and computational investigation.

ABSTRACT: Biosensitive and biologically active morpholine-based transition metal(ii) complexes (1-5) were constructed as [M^II(L) AcO]·nH₂O {where M = Cu (1) n = 1; Co (2), Mn (3), Ni (4), n = 4 and Zn (5) n = 2}, which were synthesized from 2-(-(2-morpholinoethylimino) methyl)-4-bromophenol ligand (HL) and structurally characterized by various analytical and spectroscopic techniques, which proposed a square planar and tetrahedral geometry around the central metal ion with lattice water molecules. The gel electrophoresis results revealed that complexes 1 and 5 had more potent DNA cleavage efficacy in the presence of an oxidizing agent (H₂O₂) as compared to the others. The observed DNA binding results for all the compounds as dete

SUBMITTER: Sakthikumar K 

PROVIDER: S-EPMC9064050 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature