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Comparative molecular genomic analyses of a spontaneous rhesus macaque model of mismatch repair-deficient colorectal cancer.

ABSTRACT: Colorectal cancer (CRC) remains the third most common cancer in the US with 15% of cases displaying Microsatellite Instability (MSI) secondary to Lynch Syndrome (LS) or somatic hypermethylation of the MLH1 promoter. A cohort of rhesus macaques from our institution developed spontaneous mismatch repair deficient (MMRd) CRC with a notable fraction harboring a pathogenic germline mutation in MLH1 (c.1029C

SUBMITTER: Ozirmak Lermi N

PROVIDER: S-EPMC9064097 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Comparative molecular genomic analyses of a spontaneous rhesus macaque model of mismatch repair-deficient colorectal cancer.

Ozirmak Lermi Nejla N Gray Stanton B SB Bowen Charles M CM Reyes-Uribe Laura L Dray Beth K BK Deng Nan N Harris R Alan RA Raveendran Muthuswamy M Benavides Fernando F Hodo Carolyn L CL Taggart Melissa W MW Colbert Maresso Karen K Sinha Krishna M KM Rogers Jeffrey J Vilar Eduardo E

PLoS genetics 20220421 4

Colorectal cancer (CRC) remains the third most common cancer in the US with 15% of cases displaying Microsatellite Instability (MSI) secondary to Lynch Syndrome (LS) or somatic hypermethylation of the MLH1 promoter. A cohort of rhesus macaques from our institution developed spontaneous mismatch repair deficient (MMRd) CRC with a notable fraction harboring a pathogenic germline mutation in MLH1 (c.1029C<G, p.Tyr343Ter). Our study aimed to provide a detailed molecular characterization of rhesus CR ...[more]

PMID: 35446842

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