Mycobacterium tuberculosis infection, immune activation, and risk of HIV acquisition.

ABSTRACT:

Background

Although immune activation is associated with HIV acquisition, the nature of inflammatory profiles that increase HIV risk, which may include responses to M. tuberculosis (Mtb) infection, are not well characterized.

Methods

We conducted a nested case-control study using cryopreserved samples from persons who did and did not acquire HIV during the multinational Step clinical trial of the MRKAd5 HIV-1 vaccine. PBMCs from the last HIV-negative sample from incident HIV cases and controls were stimulated with Mtb-specific antigens (ESAT-6/CFP-10) and analyzed by flow cytometry with intracellular cytokine staining and scored with COMPASS. We measured inflammatory profiles with five Correlates of TB Risk (CoR) transcriptomic signatures. Our primary analysis examined the a

SUBMITTER: Bender Ignacio RA 

PROVIDER: S-EPMC9064099 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature