New transition metal complexes with a pendent indole ring: insights into the antifungal activity and mode of action.

ABSTRACT: Development of new chemotherapeutic agents to treat multidrug-resistant fungal infections to augment the current treatment options is a must. In this direction, a series of mixed ligand complexes was synthesized from a Schiff base (L) obtained by the condensation of 2-hydroxynapthaldehyde and tryptamine, and 1,10-phenanthroline (1,10-phen) as a secondary ligand. Based on spectral characterization and physical measurements an octahedral geometry was assigned to [Co(phen)LClH₂O] (C2), [Ni(phen)LClH₂O](C3), and [Zn(phen)LClH₂O](C4) complexes while a distorted octahedral geometry was assigned to the [Cu(phen)LClH₂O](C1) complex. All the synthesized compounds were tested for antifungal activity against 11 Candida albicans isolates, including fl

SUBMITTER: Dar OA 

PROVIDER: S-EPMC9064211 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature