Early lock-in of structured and specialised information flows during neural development.

ABSTRACT: The brains of many organisms are capable of complicated distributed computation underpinned by a highly advanced information processing capacity. Although substantial progress has been made towards characterising the information flow component of this capacity in mature brains, there is a distinct lack of work characterising its emergence during neural development. This lack of progress has been largely driven by the lack of effective estimators of information processing operations for spiking data. Here, we leverage recent advances in this estimation task in order to quantify the changes in transfer entropy during development. We do so by studying the changes in the intrinsic dynamics of the spontaneous activity of developing dissociated neural cell cultures. We find that the quantity of

SUBMITTER: Shorten DP 

PROVIDER: S-EPMC9064303 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature