Bio-fabrication of pigment-capped silver nanoparticles encountering antibiotic-resistant strains and their cytotoxic effect towards human epidermoid larynx carcinoma (HEp-2) cells.

ABSTRACT: Bacterial biomolecule-mediated nanoparticle (NP) synthesis constitutes a reliable, eco-friendly approach that ameliorates green-chemistry principles. In this study, stable silver nanoparticles were synthesized by exposing aqueous silver ions to an extracellular diffusible pigment produced by Pseudomonas aeruginosa (PA6) under optimized laboratory conditions. Spectroscopic and microscopic analyses showed the typical characteristics of silver with an average size of ∼28.30 nm and spherical shape. The particles were polydispersed and showed no definite agglomeration with a zeta potential of -32.3 mV, conferring stability. Antimicrobial studies were carried out using 5, 15, 25 and 50 μg mL^-1 concentrations of pcAgNPs, which showed significant antibacterial activity toward cli

SUBMITTER: Muthukrishnan L 

PROVIDER: S-EPMC9064322 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature