Ethylene glycol coated nanoceria protects against oxidative stress in human lens epithelium.

ABSTRACT: Chronic diseases are rising in incidence and prevalence because of increases in life expectancy in many parts of the world coupled with advances in medicine which manage disease progression, rather than curing and alleviating the causes. Cataract is one such chronic condition. Identifying a therapeutic intervention that is successful in reversing or preventing cataracts may have applications for other chronic diseases of protein misfolding, such as diabetes and Alzheimer's disease as these have similar causation factors, notably oxidative stress and/or glycation. Cerium oxide nanoparticles (nanoceria) which have antioxidant, radioprotective and enzyme-mimetic properties have the potential to lead to an effective non-surgical treatment. However, nanoceria stability in physiological media is

SUBMITTER: Hanafy BI 

PROVIDER: S-EPMC9064421 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature