Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia.
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ABSTRACT:
SUBMITTER: Umehara Y
PROVIDER: S-EPMC9064429 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia.
Umehara Yui Y Kageyama Toki T Son Aoi A Kimura Yu Y Kondo Teruyuki T Tanabe Kazuhito K
RSC advances 20190529 29
Tumor-selective accumulation of gold nanorods (GNR) has been demonstrated for visualization of tumor hypoxia by photoacoustic imaging. We prepared GNRs with hypoxia-targeting nitroimidazole units (G-NI) on their surface. Biological experiments revealed that G-NI produced a strong photoacoustic signal in hypoxic tumor cells and tissues. ...[more]
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