Identification of anti-inflammatory components of raw and steamed Panax notoginseng root by analyses of spectrum-effect relationship.

ABSTRACT: To identify bioactive components of Panax notoginseng (PN) roots in raw and steamed forms, chemometrics analyses including bivariate correlation analysis and partial least squares regression were used to establish the relationships between the chromatograms and anti-inflammatory effect of PN samples. The chemical fingerprints of PN were obtained by high performance liquid chromatography. The anti-inflammatory activity was evaluated by the TNF-α and IL-6 inhibiting test. According to the results, raw PN (RPN) displayed a stronger anti-inflammatory effect compared with steamed PN (SPN) samples. Chemometrics analyses showed that notoginsenoside R₁, ginsenosides Rg₁, Re and Rb₁ were the major anti-inflammatory components of RPN, whereas ginsenosides 20(<

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC9064609 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature