Ontology highlight
ABSTRACT:
SUBMITTER: Sakakibara E
PROVIDER: S-EPMC9064734 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Sakakibara Erika E Shisaka Yuma Y Onoda Hiroki H Koga Daiki D Xu Ning N Ono Toshikazu T Hisaeda Yoshio Y Sugimoto Hiroshi H Shiro Yoshitsugu Y Watanabe Yoshihito Y Shoji Osami O
RSC advances 20190613 32
Iron(iii)- and cobalt(iii)-9,10,19,20-tetraphenylporphycenes, which possess bulky phenyl groups at the four <i>meso</i> positions of porphycene, were successfully incorporated into the haem acquisition protein HasA secreted by <i>Pseudomonas aeruginosa</i>. Crystal structure analysis revealed that loops surrounding the haem-binding site are highly flexible, remodelling themselves to accommodate bulky metal complexes with significantly different structures from the native haem cofactor. ...[more]