Targeting Stearoyl-CoA Desaturase in Solid Tumors.
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ABSTRACT:
SUBMITTER: Kubota CS
PROVIDER: S-EPMC9064960 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
Targeting Stearoyl-CoA Desaturase in Solid Tumors.
Kubota Casie S CS Espenshade Peter J PJ
Cancer research 20220501 9
Cancer cells are demarcated from normal cells by distinct biological hallmarks, including the reprogramming of metabolic processes. One of the key players involved in metabolic reprogramming is stearoyl-CoA desaturase (SCD), which converts saturated fatty acids to monounsaturated fatty acids in an oxygen-dependent reaction that is crucial for maintaining fatty acid homeostasis. As such, SCD has been identified as a potential therapeutic target in numerous types of cancers, and its inhibition sup ...[more]
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