Effect of metformin on microvascular outcomes in patients with type 2 diabetes: A systematic review and meta-analysis.

ABSTRACT:

Aims

Examine the efficacy of metformin compared to placebo or other glucose-lowering medications on microvascular outcomes in patients with Type 2 Diabetes Mellitus (T2DM).

Methods

MEDLINE, EMBASE, Web of Science, and Scopus were searched from database inception to March 2020. We included randomized clinical trials of patients with T2DM receiving metformin compared with another active glucose-lowering treatment or placebo in which a microvascular outcome was assessed. The risk of bias was assessed using the Cochrane Risk of Bias tool. Microvascular complications included kidney-related outcomes, retinopathy, and peripheral neuropathy. An inverse-weighted variance random-effect meta-analysis was performed to estimate drugs effect over microvascular disease. PROSPERO (CRD42019

SUBMITTER: Gerardo Gonzalez-Gonzalez J 

PROVIDER: S-EPMC9064963 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature