Health harms of non-medical prescription opioid use: A systematic review.

ABSTRACT:

Issues

Non-medical prescription opioid use (NMPOU) contributes substantially to the global burden of morbidity. However, no systematic assessment of the scientific literature on the associations between NMPOU and health outcomes has yet been undertaken.

Approach

We undertook a systematic review evaluating health outcomes related to NMPOU based on ICD-10 clinical domains. We searched 13 electronic databases for original research articles until 1 July 2021. We employed an adaptation of the Oxford Centre for Evidence-Based Medicine 'Levels of Evidence' scale to assess study quality.

Key findings

Overall, 182 studies were included. The evidence base was largest on the association between NMPOU and mental and behavioural disorders; 71% (129) studies reported on these outco

SUBMITTER: Werb D 

PROVIDER: S-EPMC9064965 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature