DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases.
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ABSTRACT:
SUBMITTER: Wielscher M
PROVIDER: S-EPMC9065016 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases.
Wielscher Matthias M Mandaviya Pooja R PR Kuehnel Brigitte B Joehanes Roby R Mustafa Rima R Robinson Oliver O Zhang Yan Y Bodinier Barbara B Walton Esther E Mishra Pashupati P PP Schlosser Pascal P Wilson Rory R Tsai Pei-Chien PC Palaniswamy Saranya S Marioni Riccardo E RE Fiorito Giovanni G Cugliari Giovanni G Karhunen Ville V Ghanbari Mohsen M Psaty Bruce M BM Loh Marie M Bis Joshua C JC Lehne Benjamin B Sotoodehnia Nona N Deary Ian J IJ Chadeau-Hyam Marc M Brody Jennifer A JA Cardona Alexia A Selvin Elizabeth E Smith Alicia K AK Miller Andrew H AH Torres Mylin A MA Marouli Eirini E Gào Xin X van Meurs Joyce B J JBJ Graf-Schindler Johanna J Rathmann Wolfgang W Koenig Wolfgang W Peters Annette A Weninger Wolfgang W Farlik Matthias M Zhang Tao T Chen Wei W Xia Yujing Y Teumer Alexander A Nauck Matthias M Grabe Hans J HJ Doerr Macus M Lehtimäki Terho T Guan Weihua W Milani Lili L Tanaka Toshiko T Fisher Krista K Waite Lindsay L LL Kasela Silva S Vineis Paolo P Verweij Niek N van der Harst Pim P Iacoviello Licia L Sacerdote Carlotta C Panico Salvatore S Krogh Vittorio V Tumino Rosario R Tzala Evangelia E Matullo Giuseppe G Hurme Mikko A MA Raitakari Olli T OT Colicino Elena E Baccarelli Andrea A AA Kähönen Mika M Herzig Karl-Heinz KH Li Shengxu S Conneely Karen N KN Kooner Jaspal S JS Köttgen Anna A Heijmans Bastiaan T BT Deloukas Panos P Relton Caroline C Ong Ken K KK Bell Jordana T JT Boerwinkle Eric E Elliott Paul P Brenner Hermann H Beekman Marian M Levy Daniel D Waldenberger Melanie M Chambers John C JC Dehghan Abbas A Järvelin Marjo-Riitta MR
Nature communications 20220503 1
We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1,511 independent differentially methylated loci associated with CRP. These CpG sites show correlation structures across chromosomes, and are primarily situated in euchromatin, depleted in CpG islands. These genomic loci are predominantly situated in transcription factor binding sites and ge ...[more]
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