Characterizing the diversity of MHC conserved extended haplotypes using families from the United Arab Emirates.

ABSTRACT: Aside from its anthropological relevance, the characterization of the allele frequencies of genes in the human Major Histocompatibility Complex (MHC) and the combination of these alleles that make up MHC conserved extended haplotypes (CEHs) is necessary for histocompatibility matching in transplantation as well as mapping disease association loci. The structure and content of the MHC region in Middle Eastern populations remain poorly characterized, posing challenges when establishing disease association studies in ethnic groups that inhabit the region and reducing the capacity to translate genetic research into clinical practice. This study was conceived to address a gap of knowledge, aiming to characterize CEHs in the United Arab Emirates (UAE) population through segregation analysis of h

SUBMITTER: Alnaqbi H 

PROVIDER: S-EPMC9065074 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature