Juvenile handling rescues autism-related effects of prenatal exposure to valproic acid.

ABSTRACT: Environmental factors acting on young animals affect neurodevelopmental trajectories and impact adult brain function and behavior. Psychiatric disorders may be caused or worsen by environmental factors, but early interventions can improve performance. Understanding the possible mechanisms acting upon the developing brain could help identify etiological factors of psychiatric disorders and enable advancement of effective therapies. Research has focused on the long-lasting effects of environmental factors acting during the perinatal period, therefore little is known about the impact of these factors at later ages when neurodevelopmental pathologies such as autism spectrum disorder (ASD) are usually diagnosed. Here we show that handling mice during the juvenile period can rescue a range of be

SUBMITTER: Seiffe A 

PROVIDER: S-EPMC9065111 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature