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Sodium tanshinone IIA silate increases melanin synthesis by activating the MAPK and PKA pathways and protects melanocytes from H₂O₂-induced oxidative stress.

ABSTRACT: Vitiligo is an intriguing depigmentation disorder that affects about 0.5-2% of the world population. In the past decade, first-line treatments of vitiligo have involved the use of calcineurin inhibitors and corticosteroids. Sodium tanshinone IIA sulfonate (STS) has been widely applied in the treatment of cardiovascular and cerebrovascular diseases in China. In the present study, the effect of STS on melanogenesis was confirmed in the B16F10 cells and zebrafish by direct observation. The prevention of hydrogen peroxide (H₂O₂)-induced oxidative stress has been proven to be beneficial to vitiligo patients, and STS that can protect the B16F10 cells against oxidative stress has been investigated in the present reversed study. Moreover, we found that pre-treatment with STS

SUBMITTER: Zhong H

PROVIDER: S-EPMC9065168 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Sodium tanshinone IIA silate increases melanin synthesis by activating the MAPK and PKA pathways and protects melanocytes from H₂O₂-induced oxidative stress.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Sodium tanshinone IIA silate increases melanin synthesis by activating the MAPK and PKA pathways and protects melanocytes from H2O2-induced oxidative stress.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Sodium tanshinone IIA silate increases melanin synthesis by activating the MAPK and PKA pathways and protects melanocytes from H₂O₂-induced oxidative stress.