Critical role of FPR1 in splenocyte migration into brain to worsen inflammation and ischemic brain injury in mice.

ABSTRACT: Background: Splenocyte contribution to ischemic brain injury has been suggested. It is not known whether this effect is due to systemic action or direct influence in ischemic brain tissues. It is also not known how splenocytes migrate into the brain and worsen neurological outcome after brain ischemia. We determined the role of formyl peptide receptor 1 (FPR1), a receptor expressed in monocytes, in the migration of splenocytes into ischemic brain tissues and the contribution of these splenocytes to ischemic brain injury. Methods: Mice with or without fpr1 knockout were subjected to transient focal brain ischemia. The migration of splenocytes was assessed under in vivo and in vitro conditions. Results: cFLFLF, a FPR1 antagonist, inhibited splenocyte

SUBMITTER: Li J 

PROVIDER: S-EPMC9065176 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature