Sequential therapy for pancreatic cancer by losartan- and gemcitabine-loaded magnetic mesoporous spheres.

ABSTRACT: Sequential therapy has attracted increasing attention for cancer treatment, in which multiple drugs can be used to enhance the therapeutic efficacy. In this work, sequential therapy is demonstrated using amino functionalized Fe₃O₄ embedded periodic mesoporous organosilica spheres (Fe₃O₄@PMO-NH₂) and Fe₃O₄@PMO as drug carriers. Losartan can inhibit type I collagen and hyaluronic acid of the pancreatic cancer matrix, which is safe and inexpensive, and does not increase the risk of tumor metastasis. First, losartan is loaded in the Fe₃O₄@PMO-NH₂ (Fe₃O₄@PMO-NH₂-Los) to treat pancreatic cancer. Immunohistochemistry staining of tumor slices after treatmen

SUBMITTER: Li Y 

PROVIDER: S-EPMC9065328 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature