Comprehensive study on the degradation of ochratoxin A in water by spectroscopic techniques and DFT calculations.

ABSTRACT: Ochratoxin A (OTA) is one of the most important dietary risk factors and is classified as a possible carcinogen to humans. Assessing the conditions to remove it from foodstuffs in a simple and effective way is of the utmost importance. OTA behaviour in water in the pH range 1.0-12.5 was elucidated to investigate the conditions for irreversible toxicity inactivation of OTA. The results indicate that four forms, from neutral to trianionic, intervene depending on the pH. pK _a1,2 were rigorously established by independent spectroscopic techniques to overcome the scarcity of literature. Then, Density Functional Theory (DFT) calculations were used to determine the most probable degradation mechanism and this was confirmed by fluorescence spectroscopy. At pH 12.5, hydrolyzation

SUBMITTER: Cagnasso I 

PROVIDER: S-EPMC9065388 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature