Revisiting brain iron deficiency in restless legs syndrome using magnetic resonance imaging.

ABSTRACT:

Study objectives

Studies on brain iron content in restless legs syndrome (RLS) using magnetic resonance imaging (MRI) are heterogeneous. In this study, we sought to leverage the availability of a large dataset including a range of iron-sensitive MRI techniques to reassess the association between brain iron content and RLS with added statistical power and to compare these results to previous studies.

Methods

The relaxation rates R₂, R₂', and R₂* and quantitative susceptibility are MRI parameters strongly correlated to iron content. In general, these parameters are sensitive to magnetic field variations caused by iron particles. These parameters were quantified within iron-rich brain regions using a fully automatized approach in a cohort of 72

SUBMITTER: Beliveau V 

PROVIDER: S-EPMC9065426 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature