Structural characterization of phosphoethanolamine-modified lipid A from probiotic Escherichia coli strain Nissle 1917.

ABSTRACT: Gut microbiota, a complex microbial community inhabiting human or animal intestines recently regarded as an endocrine organ, has a significant impact on human health. Probiotics can modulate gut microbiota and the gut environment by releasing a range of bioactive compounds. Escherichia coli (E. coli) strain Nissle 1917 (EcN), a Gram-negative bacterial strain, has been used to treat gastrointestinal (GI) disorders (i.e., inflammatory bowel disease, diarrhea, ulcerative colitis, and so on). However, endotoxicity of lipopolysaccharide (LPS), a major component of the cell wall of Gram-negative bacteria in the gut, is known to have a strong influence on gut inflammation and maintenance of gut homeostasis. Therefore, characterizing the chemical structure of lipid A which det

SUBMITTER: Jo SH 

PROVIDER: S-EPMC9065436 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature